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Dr. Harding prepares and prosecutes U.S., international and foreign patent applications. She also prepares legal opinions, including patentability, inventorship, freedom to use, and infringement/non-infringement opinions. License negotiations and client counseling regarding portfolio management are additional aspects of Dr. Harding's work.
Technical Expertise
Dr. Harding's technology areas include molecular and cell biology, cancer and immunology, infectious diseases (including viral diseases), vaccines, and microarray and high throughput technologies (including nucleic acid and protein arrays). She has extensive laboratory experience in recombinant DNA techniques, protein isolation and analysis, immunology, and molecular and microbial genetics. Research systems include tobacco, tomato, barley, wheat, and cucumber, as well as bacteria, yeast (S. cerevisiae), and Chlamydomonas.
Bar Admissions
Oregon, 1999
U.S. Patent and Trademark Office (Reg. No. 42,630)
Prior Professional Experience
U.S. District Court - Northern District of N.Y., Hon. Thomas J. McAvoy, Chief Judge, Binghamton, NY
Judicial Externship, Spring 1998
Legal research and preparation of bench memoranda related to federal law and litigation.
Cornell University Law School, Ithaca, NY
Research Assistant to Professor Yvonne Cripps, Fall 1997
Assisted with on-line and library research related to the legal and ethical issues raised by human cloning and genetic engineering. Reviewed and analyzed related court cases and commentaries related to the overlap between legal, scientific, and ethical issues.
Sterne, Kessler, Goldstein & Fox P.L.L.C., Washington, D.C.
Summer Associate, May 1997 - August 1997
Prosecution of U.S., international, and foreign patent applications. Technology areas includes molecular and cell biology, cancer, and immunology. Preparation of patentability opinions. Reviewed and analyzed patent portfolios for corporate clients.
University of California, Davis, CA
Teaching Assistant, Department of Microbiology, Spring 1995
Small group teaching responsibilities for two sections of students (~30 in each section) in survey course in Biology. Responsibilities included weekly laboratories, administration and grading of quizzes and exams, office hours consultations with individual students. Lectured to class (~250 students) on molecular biology and genetics.
Graduate Research Associate, Depts. of Microbiology and Plant Biology, May 1991-June 1996
Extensive experience with recombinant DNA techniques (including DNA/RNA sequencing, PCR, plasmid construction and transformation), protein isolation and analysis (including column chromatography, SDS-PAGE and immunoblotting), and molecular and microbial genetics. Experience with plant tissue culture, electron microscopy, and calorimetry. Worked in various plant and microbial systems.
Presentations and Publications
Harding, T.M., Morano, K.A., Scott, S.V. and Klionsky, D.J. (1995). Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J. Cell Biol., 313:591-602.
Kim, J., Alizadeh, P., Harding, T.M., Hefner-Gravink, A., and Klionsky, D.J. (1996) Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: Potential commercial applications. Appl. Environ. Microbiol., 62:1563-1569.
Harding, T.M., Hefner-Gravink, A., Thumm, M., and Klionsky, D.J. (1996). Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J. Biol. Chem., 271:17621-17624.
Wang, Y.-X., Xhao, H., Harding, T.M., Gomes de Mesquita, D.S., Woldringh, C.L., Klionsky, D.J., Munn, A.L., and Weisman, L.S. (1996). Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Mol. Biol. Cell, 7:1375-1389.
Professional Activities
Member, American Intellectual Property Law Association, Multnomah Bar Association, Oregon State Bar Association, and American Bar Association
Participant and mentor in the Multnomah Bar Association Mentorship Program
Representative Patents
Activating mutations of platelet derived growth factor receptor alpha (PDGFRA) as diagnostic markers and therapeutic targets
Enhanced protein separation and analysis
Inhibitor of DNA methylation
Latent human tuberculosis model, diagnostic antigens, and methods of use
Measurements of multiple molecules using a cryoarray
Methods and arrays for detecting biomolecules
Oxidation-reduction sensitive green fluorescent protein variants
Phenylthiocarbamide (PTC) taste receptor
Systems for in vivo site-directed mutagenesis using oligonucleotides
Systems for in vivo site-directed mutagenesis using oligonucleotides
Systems of transferring embryos and managing recipients
Year Joined Firm
1999 |
