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Paul Klotman, MD is the Murray M. Rosenberg Professor of Medicine and the Chairman of the Samuel Bronfman Department of Medicine at the Mt. Sinai School of Medicine. Dr. Klotman’s research has been focused on the translation of molecular virology to AIDS pathogenesis. His laboratory developed the first small animal model of HIV associated nephropathy, demonstrating HIV causes HIVAN directly. More recent work has shown that HIV replicates in human renal epithelium, that the kidney is a reservoir for replicating virus and that the renal epithelium serves as a compartment distinct from peripheral blood. His laboratory has demonstrated the importance of the Nef gene in causing cellular proliferation through the Src pathway as a key component of renal pathogenesis. Dr. Klotman has been elected to both the American Society of Clinical Investigation and the Association of American Physicians. He has served on and chaired numerous study sections including those from the NIH, the American Heart Association, the National Kidney Foundation, and the Veterans Affairs research service. | 