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A senior physician at the Brigham and Women's Hospital and Professor of Medicine at Harvard Medical School, Dr. Martin Carey was awarded the Beaumont Prize of the AGA in May 2000. His research focuses on several topics involving lipids of the hepatobiliary system important in human health and disease. Dr. Carey's research on pathophysiology of bile involves physical-chemical and molecular biologic experiments in model systems, ex vivo hepatobiliary tissues, and mouse models. His work on the genetics of cholesterol gallstone formation involves inbred mice of different strains as well as recombinant inbred, congenic, and various "knock-out" and "knock-in" mice to answer specific questions. The overall strategy is to identify and determine the functions of all the major murine cholesterol gallstone (Lith) genes as a framework for human LITH gene discovery. | 