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John W. Mellors, MD is a tenured Professor of Medicine and Chief of Infectious Diseases at the University of Pittsburgh School of Medicine. He is also the Executive Director of the HIV Program at the University of Pittsburgh Medical Center (UPMC), which provides comprehensive primary care and access to clinical trials for HIV-infected individuals. Dr. Mellors' research focuses on the genetic, biochemical and structural mechanisms of HIV drug resistance and the application of this knowledge to improving treatment response in patients with drug-resistant HIV. His laboratory has helped define the mechanisms responsible for HIV resistance to nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and the pyrophosphate analog, phosphonoformic acid. His clinical research efforts have helped establish the relationship between viremia and clinical outcome in HIV-1 infection and between drug resistance and treatment response in antiretroviral-experienced patients. He is a member of the US Public Health Service Panel on Clinical Practices for the Treatment of HIV Infection, and the International AIDS Society-USA Panel on HIV drug resistance. | 