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On September 26, 2007, our Board of Directors elected John R. Leone as our lead director. Mr. Leone was elected a director on June 29, 2007. He is currently a partner at Paul Capital Partners. He has over 30 years of pharmaceutical industry experience. In 2004 and 2005 he was president and chief executive officer of Cambrex Corporation, a leading life sciences company. From 2000 to 2004 he was at Aventis, where he served as senior vice president and chief operating officer of U.S. Commercial Operations. Among other initiatives, he spearheaded the successful integration of Rhone-Poulenc Rorer and Hoechst Marion Russell to form Aventis. His industry experience also includes both domestic and international management roles with Pfizer and Wyeth. He received his BS degree in Engineering from the U.S. Military Academy at West Point and his MBA from the University of Colorado | 