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Professor Bush is the Australian Research Council Federation Fellow at the Mental Health Research Institute of Victoria (Australia) and a co-founding scientist of Prana.
Professor Bush studies the major proteins implicated in Alzheimer‘s disease that aggregate to cause plaques. Copper/zinc-binding proteins, whose physiochemical properties (e.g. solubility), are profoundly influenced by interaction with metal ions. Dr. Bush‘s lab has developed new drugs based on metals theory that are being tested in the clinic.
Professor Bush‘s lab also explores the causes of severe oxidative stress in the brain as it relates to Alzheimer‘s disease, as well as the relationship between amyloid deposition in the brain (the typical pathology of Alzheimer‘s disease) and oxidation injury. | 